Introduction The aim of this article is to provide an overview of the risks associated with the viral infection known as yellow fever and to review the merits of immunisation against it. It will examine the endemnici-ty, clinical signs and symptoms and prevention of this re-emerging disease. After reading this article you should be able to: ■Describe where yellow fever occurs ■Outline how yellow fever is transmitted to human beings ■Describe the presenting features of yellow fever as an illness ■Discuss the indications and contraindications of yellow fever vaccination ■Summarise the regulations associated with international vaccination certificates ■Outline what is involved in becoming a registered yellow fever centre.